Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4520)
Related Products (4520)
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1-Methylimidazole-d3-1
0 ImagesCat. No.: HY-59137S2CAS No.: 4166-68-11-Methylimidazole-d3-1 is the deuterium labeled 1-Methylimidazole. 1-Methylimidazole acts as a membrane performance regulator that promotes the formation of reverse osmosis membranes with a dense ultra-thin polyamide layer. Such membranes exhibit higher flux and salt rejection rate, while also conferring excellent pH stability to the membrane. 1-Methylimidazole can serve as a ligand for ruthenium (II) complexes to construct metal-based anticancer agents.
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ProX1-(SS)-DOTAGA
0 ImagesCat. No.: HY-185120ACAS No.: 3084147-67-8ProX1-(SS)-DOTAGA (Compound 12b) is the unbound portion of the radionuclide in the compound and can be used for targeted delivery to diseases characterized by ACP3 expression.
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H-Arg-Ser-Arg-OH
0 ImagesCat. No.: HY-134578CAS No.: 115035-42-2H-Arg-Ser-Arg-OH is a short peptide. H-Arg-Ser-Arg-OH is a motif of di-leucine and RSRR, it can be used to design larger peptides and compound.
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Antitumor agent-90
0 ImagesCat. No.: HY-153051CAS No.: 131268-74-1Antitumor agent-90 (Compound 17) has cytotoxicity against PC 14 cell and MKN 45 cell. Antitumor agent-90 can be used for cancer research.
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Fosamprenavir sodium
0 ImagesCat. No.: HY-78726ACAS No.: 226700-80-7Synonyms: Amprenavir phosphate sodium; GW 433908 sodiumFosamprenavir sodium is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir sodium is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir sodium can be used for the study of human immunodeficiency virus (HIV-1) infection.
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5,8-Dimethoxyquinoxaline
0 ImagesCat. No.: HY-W1063697CAS No.: 19506-19-55,8-Dimethoxyquinoxaline is a drug intermediate that can be used in studies related to organic synthesis. The derived cyclization product of 5,8-Dimethoxyquinoxaline specifically blocks TOP1-mediated DNA cleavage reactions.
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Antiproliferative agent-48
0 ImagesCat. No.: HY-163381CAS No.: 1621594-62-4Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells.
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Chloramphenicol succinate
0 ImagesChloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease.
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2,4-Dihydroxybenzaldehyde (Standard)
0 Images2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions.
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Anticancer agent 346
0 ImagesCat. No.: HY-184941CAS No.: 3099596-05-8Anticancer agent 346 is an anticancer agent. Anticancer agent 346 exhibits anticancer activity against breast cancer.
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Acetylpyrazine (Standard)
0 ImagesCat. No.: HY-W007692RCAS No.: 22047-25-2Synonyms: 2-Acetylpyrazine (Standard)Acetylpyrazine (2-Acetylpyrazine) (Standard) is the analytical standard of Acetylpyrazine. This product is intended for research and analytical applications. Acetylpyrazine is a ketone compound and can be used for drug synthesis.
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Lipoxin B4 methyl ester
0 ImagesCat. No.: HY-134123CAS No.: 97589-07-6Synonyms: LXB4 methyl esterLipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
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Bimatoprost isopropyl ester
0 ImagesCat. No.: HY-116161CAS No.: 130273-87-915(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
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D-Lyxose-d
0 ImagesCat. No.: HY-128753S6CAS No.: 288846-88-8D-Lyxose-d is the deuterium labeled D-Lyxose. D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose sugar with significant potential for drug synthesis. D-Lyxose can be used as a starting material for anti-tumor drugs such as alpha galactose ceramide immunostimulants. D-Lyxose can be used as a precursor for L-nucleoside analogs for the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars such as L-ribose.
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TRPM8 antagonist 4 prodrug
0 ImagesCat. No.: HY-174846TRPM8 antagonist 4 prodrug (Compound 8b) is an orally active CB2R agonist (EC50: 51.2 nM) and a weak TRPM8 antagonist. TRPM8 antagonist 4 prodrug is a prodrug of TRPM8 antagonist 4 (HY-174825). TRPM8 antagonist 4 prodrug exhibits anti-inflammatory and analgesic activities and can be used in the research of inflammation-related pain disorders.
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4-Fluorobenzoic acid-13C6
0 ImagesCat. No.: HY-W013677S4-Fluorobenzoic acid-13C6 is the 13C6 labeled 4-Fluorobenzoic acid (HY-W013677). 4-Fluorobenzoic acid is a drug intermediate that can be used to synthesize a series of hydrazone derivatives with antituberculosis activity and Schiff bases with DPPH radical scavenging activity.
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L-Xylose (Standard)
0 ImagesL-Xylose (Standard) (L-(-)-Xylose (Standard)) is the analytical standard of L-Xylose (HY-78139). This product is intended for research and analytical applications. L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules.
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L-Proline 4-methoxy-β-naphthylamide hydrochloride
0 ImagesCat. No.: HY-131096CAS No.: 100930-07-2Synonyms: H-Pro-4MβNA hydrochlorideL-Proline 4-methoxy-β-naphthylamide hydrochloride (H-Pro-4MβNA hydrochloride) can be used for Fap-activated anti-tumor compounds preparaction.
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2-Acetylpyrrole (Standard)
0 Images2-Acetylpyrrole (Standard) is the analytical standard of 2-Acetylpyrrole (HY-W012956). This product is intended for research and analytical applications. 2-Acetylpyrrole is an organic compound containing a pyrrole ring. 2-Acetylpyrrole is one of the products of the Maillard browning reaction and can serve as a major flavor component in many foods. As an intermediate, 2-acetylpyrrole can also be used in the synthesis of other active compounds, such as the flavor compound 2-acetyl-1-pyrroline.
